![]() Most commonly, a first-order absorption process is used to describe the observed data. The absorption rate constant has units of inverse time. The absorption rate measures the rate at which drug moves from the intestinal tract into the systemic circulation. ![]() Eventually drug makes its way through the liver and into the systemic circulation. ![]() The drug is then absorbed across the intestinal wall and into the portal vein. The pill then moves through the intestinal tract (stomach, small intestine, large intestine) disintegrating along the way. A drug is contained within a pill and is ingested by swallowing with liquid (usually water). Let’s consider the case of oral administration first, then we can discuss other routes of administration. This is probably one of the simplest pharmacokinetic (PK) parameters to explain and understand. The rate at which a drug enters the body after administration is called the absorption rate, and is represented by the symbol k a.
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